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By attenuating NNMT activity, 5Amino1MQ has been observed in preclinical settings to elevate NAD+ availability, enhance metabolic flux, and upregulate downstream signaling programs associated with cellular stress responses and energy expenditure (e.g., SIRT1)

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A deficiency in *thiamine* can lead to neurological disorders, including peripheral neuropathy, which manifests as numbness, tingling, and weakness

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